Prevalence of extended-spectrum β-lactamase producing isolates from asymptomatic bacteriuria among students in a tertiary institution in ibadan, Nigeria.

Indiscriminate use of antibiotics, particularly the extended-spectrum antibiotics in Nigeria has assisted the principle of selection pressure for the highly resistant strains of bacteria. The aim of this study is to investigate the prevalence of asyptomatic bacteriuria as well as antibiotic susceptibility and extended-spectrum beta-lactamase production among bacterial isolates from healthy students in a tertiary institution in southwest Nigeria. The results of the mid-stream urine catch that was collected and analysed in a total of 100 students , all within the age range 17 to 26 years, were found to contain bacterial isolates of Staphylococcus aureus (5%), Escherichia coli (3%), Citrobacter frundii (4%), Proteus spp. (26%), Klebsiella spp. (40%), Moganella morganni (4%) and Providencia stuartii (4%). Visible bacterial growth occurred in 86% of the urine samples with 41% from males and 45% from females. Antibiotics such as penicillin, cephalosporin, quinolone, aminoglycoside, macrolide and nitrofuran were used for antibiotic susceptibility test against the isolates. Extended-spectrum beta-lactamase production was determined among cephalosporin resistant Gram-negative isolates. This study showed high prevalence of asymptomatic bacteriuria associated with multidrug resistance and some ESBL-producing bacteria among healthy students of University of Ibadan. Thus concerted effort in the control of the use of extended-spectrum antibiotics should be made, so as to avoid high prevalence of human reservoirs of multidrug resistant and ESBL-producing bacteria. http://www.sciencepub.net/nature . (Alabi O. S., Onyenwe N. E., Satoye K. A. and Adeleke O. E. Prevalence of extended-spectrum β-lactamase producing isolates from asymptomatic bacteriuria among students in a tertiary institution in ibadan, Nigeria. Nat Sci 2014;12(4):111-114). (ISSN: 1545-0740). http://www.sciencepub.net/nature . 15