Regenerative Endodontic Management of a Periapical Lesion using Platelet Rich Fibrin: A Case Report

Periapical inflammatory lesions occur in response to the ingress of microbes from the root canal. The treatment rendered in endodontic procedures includes root canal cleaning and shaping followed by obturation. In an event when the pathology cannot be cleaned due to obturation, surgical intervention has to be delivered. The rationale of surgical endodontics is to eliminate the pathological tissue in an infected necrotic tooth present at the apex of a root canal and throughout the apex and retrofill the space inside the root canal with biologically inert material so as to achieve a tight seal. Herein we are documenting a case report of 26-year-old male patient with a chief complaint of swelling and pain in the upper front teeth region and a large bony defect radiologically in which a periapical endodontic surgery was performed. The surgical defect was filled with platelet-rich fibrin (PRF). Clinical examination revealed uneventful wound healing. Radiologically, the defect has been almost entirely replaced by new bone at the end of 8 months. On the evidence of the outcomes obtained in our case report, we hypothesize that healing process was enhanced by an autologous PRF and can be used as a regenerative material of choice in such type of endodontic procedures.