Analysis of therapeutic effects for 76 cases of brucellosis

Objective To explore the curative effects for acute and subacute brucellosis by different therapeutic methods. Methods 76 cases of acute and subacute of brucellosis patients were randomly divided into two groups (40 cases in survey group and 36 cases in control group). The patients in control group were given rifampin, doxycycline, while the survey group were given rifapentine, doxycycline and ceftazidime. All the patients were treated for 6 weeks and followed-up for 6 months. Results The symptoms of fever, hyperhidrosis, arthralgia, enlargement of lymph nodes in liver and spleen in suvey group disappeared in a short time as compared with control group, there were statistical differences(t =7.37,4.62,4.18,3.86, P＜ 0.01). The normalized time of routine blood, ESR and blood or bone marrow culture in survey group were significantly shorter than those in control group (t = 6.39, 5.42,5.78, P ＜ 0.01). The total effective rate was 95.00% in survey group (36 cases were curative, 2 cases had therapeutic effects); wihle total effective rate in control group was 77.78% (24 cases were curative, 4 cases had therapeutic effects). There was a statistical significance between the two groups (x2 = 4.92, P ＜ 0.05). Conclusions Clinical effect of rifapentine, doxycycline ceftazidime combination for acute and subacute brucellosis is good, it is worth for application. Key words: Brucellosis;  Rifapentine;  Ceftazidime;  Doxycycline