The Relationship Study of Homocysteine (Hcy) and Stroke

Objective To evaluale the level of Hcy in subtype of cerebral ischemic disorders and cerebral hemorhage and to observe the correlative factors. Methods A case - control study, were perfomed 450 cases with acute cerebral infarction (CD or transient ischemic attacks (TIA) or cerebral hemorrhage (CH) Were enrolled. 149 cases were used as control. All the subjects underwent transcranial Doppler and plasma Hey examination. Results Mean plasma Hcy were significantly higher in the all three groups (Group CI 20. 82 ± 11. 86 umol/L, Group TIA 20. 61 ± 13. 73 u-mol/L and Group CH 24. 78±12. 75 umol/L), comparing with normal control (9. 84 ± 2. 55 umol/L, P0. 01). The Mean plasma Hcy were higher in the group of CI patients than in the group of CH patients ( P = 0. 041). The ratio of hyperhomocysteine in CH 75. 5%)is significantly higher than in CI (56. 5%) and TIA (48. 6%), P0. 05. The Odds ratio of CI, TIA and CH of hyperhomocysteine was 1. 670 (95% CI,1. 089-2. 562), 1. 654(95%CI 0. 828-3. 302), 2. 454 (95%CI, 1. 479 - 4. 071). There was no significant difference between cerebral vascular stenosis and hyperhomocysteine in patients with ischemic stroke. The level of Hcy in the patients with coexisting diabetes (16. 14 ± 7. 82 umol/ 1) was significantly lower than that in the patients with no diabetes (22. 55 ± 12. 66 umol/l), P0. 01. Conclusion There is a significantly association between hyperhomocystinemia and ischemic cerebrovascular disease or CH. The frequency of hy perhomocysteine in CH is higher than in Cl and TIA. CH is significantly correlated with increased Hcy. The correlation of cerebral vascular stenosis and the level of Hcy is not found in this study. The level of Hcy has an important influence on stroke in the patients of cerebral stroke with no diabetes.