Inflammatory response to coronary stenting in patients with stable angina

Objective:To evaluate inflammatory response to PCI in patients with stable coronary artery disease. Method:We analyzed clinical data of 78 patients retrospectively,and divided into restenosis group(10 cases) and non restenosis group(68 cases) according to the coronary angiography result that executed again 6-months after PCI.Then we measured the level of hs-CRP,VCAM-1,ICAM-1 pre-PCI,pos-PCI,24 hours after PCI(24 h-PCI),72 hours after PCI(72 h-PCI) respectively. Result:In all patients after PCI,hs-CRP,VCAM-1 level were significantly higher than pre-PCI.In restenosis group,hs-CRP and VCAM-1 level in 72 h-PCI were higher than those in non restenosis group [(9.81±4.76)mg/dl vs(6.64±2.89)mg/dl,P0.01];[(109.45±48.93)ng/ml vs(86.64±42.62)ng/ml,P0.05];hs-CRP level in 24 h-PCI was higher in restenosis group than in non restenosis group [(3.77±1.52)mg/dl vs(2.43±1.05)mg/dl,P0.05].There was no significant difference of ICAM-1 between 2 groups,while in restenosis group,the ICAM-1 level in 72 h-PCI was higher than before [(7.23±3.46)ng/ml vs(4.35±2.07)ng/ml,P0.05]. Conclusion:In patients with stable angina,the increasing level of hs-CRP,VCAM-1 after PCI maybe indicate the restenosis after PCI.If the level of ICAM-1 in 72 h-PCI is higher than pre-PCI,it also can be regarded as a predictor of restenosis.