117 Placental growth factor rating (PLGF) in the prediction of preeclampsia

Introduction The use of such markers in predicting preeclampsia, such as PlGF, can serve in predicting the syndrome, and precocious identification can anticipate management and decrease the risks. Objective To evaluate among pregnant women, both those who developed pre-eclampsia as those who did not developed hypertensive disorder complications, the role of placental growth factor (PlGF) as predictor of the syndrome in question, pre-eclampsia. Methods From the MEDLINE database, articles were extracted using the following keywords: (placental growth factor OR PLGF) AND pre-eclampsia/diagnosis by selecting, from a total of 193 retrieved in the search, papers published from 2014 to produce a systematic review. Were excluded narrative and systematic reviews, and in addition, the selected study models included cohort and case-control, which analyzed PlGF alone, sFlt-1/PlGF ratio, PlGF associated with other biomarkers of PE, Doppler Velocimetry uterine artery added to the PlGF and other biomarkers, getting a total of 25 articles after three independent reviewers to analyze the search results and confront their findings. Results Although there is no agreement in all literature about the PlGF levels during pregnancy, the studies evaluated showed a standardization of variations in the marker values during gestation, which are reduced in the preeclampsia group compared to controls, and further reduced in early and severe preeclampsia. On average, pregnancies that resulted in the disease did not show values above 208 pg/ml, unlike the pregnancies in the control group who always obtained values above 300 pg/ml, usually in the second quarter. Recalling that, in the latter group, it kept growing with the evolution of pregnancy. The association of PlGF to Doppler velocimetry of the uterine artery, or other biomarkers or both leads to an increase in the accuracy of the tests. But we can see that the evaluation of sFlt-1 ratio/PlGF is the parameter that brings greater sensitivity and specificity in predicting preeclampsia. Conclusion According to gestational age, PlGF levels have a pattern of variability that differs in healthy women compared to that present the syndrome in question. The latter has lower PlGF values than the control group, and the difference is even greater when you have early or severe PE. Disclosure of interest None declared.