Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

The syndecan binding protein syntenin promotes the budding of intraluminal vesicles from the endosomal membrane, resulting in increased exosome secretion. Ghossoub et al. show that syntenin activates a pathway including ADP-ribsoylation factor 6 and phospholipase D to stimulate budding.