Effect of Ovariectomy on Serum Lipid Peroxide Levels in Women

Serum lipid peroxide levels of normal premenopausal women were lower than those of normal postmenopausal women. When premenopausal women received bilateral ovariectomy, their serum lipid peroxide levels were significantly increased when examined 15 days after the operation as compared with their levels before the operation, and these levels remained high even when measured at 60 days after the operation. On the contrary, no change was found in another group of premenopausal women who had received hysterectomy with unilateral ovariectomy. These results support the view that female hormones have a preventive effect on an increase in serum lipid peroxide levels in women.