Chemical Incorporation of Antioxidants into a Biodegradable Polymer for Controlled Release

Reactive oxygen species (ROS) in life organisms are produced as well as antioxidants, which are bioactive compounds that can counteract the effect of such harmful species. Under UV light and other stress situations, natural inhibitors aren’t enough to react with ROS, causing redox misbalance and aging. In order to replace these antioxidants, we will show the development of a biodegradable and biocompatible catechol-based poly (anhydride-esters). This polymer is designed to break down and release controllably the antioxidant after hydrolysis of anhydride and ester bonds.