Acute Myeloid Leukemia With Translocation 8;16: A Rare Recurrent Cytogenetic Abnormality With Distinct Clinicopathologic Findings

Recurrent genetic abnormalities are important prognostic markers in acute myeloid leukemias (AML). The World Health Organization classification recognizes 7 categories of AML with recurrent cytogenetic abnormalities, all balanced translocations. Additional rare recurrent cytogenetic abnormalities, such as t(8;16)(p11;p13), are described, but their clinicopathologic correlations are not well established. We reviewed the bone marrow morphology, blast immunophenotype, and clinical features …