Synthetic, structural and pharmacological studies on some isonicotinohydrazide and benzohydrazide analogues

Abstract Aim A series of new isonicotinohydrazide and benzohydrazide analogues were synthesized by conventional one pot reaction of isoniazid and benzhydrazide with various disubstituted benzaldehydes in ethanol. Methods The isonicotinohydrazide and benzohydrazide derivatives were prepared by the reaction between the corresponding substituted benzaldehyde (10 mmol) with isoniazid and benzhydrazide (10 mmol) in ethanol (30 mL). Results The synthesized compounds were characterized by Elemental analyses, LC-MS, FT-IR, 1 H NMR and 13 C NMR and evaluated for their in vitro antimicrobial activity against Mycobacterium tuberculosis H 37 Rv (MTB). Conclusion The syntheses of the 12 derivatives were performed. In relation to the biological studies, it was found that the compounds A6 and C6 showed higher activity against all the tested bacterial strains and the compounds A1–A6 exhibited the highest efficacy and exhibited >70% inhibition against the M. tuberculosis .