Bullous fixed drug eruption following Human Papilloma Virus (HPV) vaccination.
2020
An otherwise healthy 13-year-old girl developed a bullous skin reaction on the upper arm 2 hours following the intramuscular administration of Cervarix((R)) (GSK, Rixensart, Belgium), a bivalent vaccine targeting Human Papilloma Virus (HPV) types 16 and 18. She had received a first and uncomplicated dose of the vaccine eight months earlier. Clinical examination showed a localized, painful, erythematous area of 7 by 5 centimetres on the right upper arm, accompanied by clear skin epidermolysis with bulla formation and a positive Nikolsky sign, not extending beyond the borders of the erythematous area (Figure 1).
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