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herbal treatment for type 2 diabetes compared to current medicines
2018
1. Abstract 1.1. Objective : To study the effect of herbal treatment for type 2 diabetes
compared to current medicines. 1.2. Method: Total of 24 Locally bred male Albino Wistar rats weighing
180 to 200gm, purchased from research institute of Agha Khan University Karachi
Pakistan were used throughout the experiments. These rats were divided into 4
groups containing 6 rats in each group: Control (C), Model (M), Test 1 (T1) and
Test 2 (T2). C was given as 0.9% saline solution. M and both test groups were
treated with streptozotocin (STZ) as 30mg/kg body weight intraperitonially for
4 weeks (twice a day) to produce the hyperglycemic effects. After 4 weeks, rats
were fasted for 16 hours and with one drop of blood from tail plasma glucose
was checked by using glucometer. After STZ treatment T1 group treated with
metformin 100mg/kg body weight given orally and T2 with a self-prepared 100mg
tablets of black pepper powdered in extraction of small new sprouting leaves of
Azadirachta
indica (Neem tree) twice a day for three weeks. Behavioral activity
was noted. After 3 weeks of treatment rats were decapitated, and the blood
collected for biochemical activity. Statistical Package for Social Sciences
(SPSS) v.20 was used for statistical analysis. 1.3. Results: Results show that
locomotor activity of test 2 group of rats increases as compare to test 1 and
model group. Similarly, stimulatory activity of rats also increases. Results
also indicates that anxiety of test 2 group of rats decreases and recognition
memory non-significantly increases in test 2 group of rats as compare to test 1
and model groups. Biochemical parameters including random plasma glucose and
serum cholesterol were significantly (P<0.05) decreased in test 2 group of
rats as compare to test 1 and model group of rats. 1.4. Conclusion: Herbal treatment with
metformin and modification of lifestyle were highly effective means of delaying
or preventing type 2 diabetes. It was also concluded that herbal treatment for
type 2 diabetes is one of the treatment option which not only prevent the
development of complications but substantially reducing the individual and
public health burden of diabetes. 2. Keywords: Azadirachta indica ; Black Pepper; Type
2 Diabetes
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