GW29-e1723 Age-related downregulation of Sirt6/Nrf2 signal axis contributes to the increased heart ischemic intolerance in aged mice

To explore the role of Sirt6/Nrf2 signal axis in age-related heart ischemic intolerance and further determine the feasibility of manipulating Sirt6/Nrf2 signal as an effective strategy to combat this increased susceptibility. Cardiac-specific SIRT6 knockout mice(SIRT6-CKO) and adenovirus mediated