Dedicated cone-beam breast CT using laterally-shifted detector geometry: Quantitative analysis of feasibility for clinical translation.

BACKGROUND: High-resolution, low-noise detectors with minimal dead-space at chest-wall could improve posterior coverage and microcalcification visibility in the dedicated cone-beam breast CT (CBBCT). However, the smaller field-of-view necessitates laterally-shifted detector geometry to enable optimizing the air-gap for x-ray scatter rejection. OBJECTIVE: To evaluate laterally-shifted detector geometry for CBBCT with clinical projection datasets that provide for anatomical structures and lesions. METHODS: CBBCT projection datasets (n = 17 breasts) acquired with a 40x30 cm detector (1024x768-pixels, 0.388-mm pixels) were truncated along the fan-angle to emulate 20.3x30 cm, 22.2x30 cm and 24.1x30 cm detector formats and correspond to 20, 120, 220 pixels overlap in conjugate views, respectively. Feldkamp-Davis-Kress (FDK) algorithm with 3 different weighting schemes were used for reconstruction. Visual analysis for artifacts and quantitative analysis of root-mean-squared-error (RMSE), absolute difference between truncated and 40x30 cm reconstructions (Diff), and its power spectrum (PSDiff) were performed. RESULTS: Artifacts were observed for 20.3x30 cm, but not for other formats. The 24.1x30 cm provided the best quantitative results with RMSE and Diff (both in units of mu, cm-1) of 4.39x10-3+/-1.98x10-3 and 4.95x10-4+/-1.34x10-4, respectively. The PSDiff (>0.3 cycles/mm) was in the order of 10-14mu2mm3 and was spatial-frequency independent. CONCLUSIONS: Laterally-shifted detector CBBCT with at least 220 pixels overlap in conjugate views (24.1x30 cm detector format) provides quantitatively accurate and artifact-free image reconstruction.