Evaluation of mephentermine-prethcamide and norepinephrine- nikethamide in the management of thiopentone induced cardiopulmonary dysfunction in buffalo calves

The study was done to evaluate combinations of mephentermine-pretheamide and norepinephrine-nikethamide in the management of thiopentone induced cardiopulmonary dysfunction in buffalo calves. Heart rate increased markedly after mephentermine and prethcamide administration with values remaining higher than those recorded during circulatory insufficiency. Mephentermine and prethcamide ameliorated thiopentone induced hypotension. Central venous pressure was much lower than the base values. Respiratory rate and minute volume remained higher than the respective base values after mephentermine and prethcamide administration. The elevated blood glucose was further increased after mephentermine and prethcamide. Cardiovascular effects of norepinephrine started 0.82±0.13 min after the start of the drip and near normal range of arterial pressure was achieved at 1.25±0.4 min. Each increment of nikethamide caused transient increase in MAP by 8.28±1.2 kPa (62.14±9.57 mmHg). After an initial increase, heart rate was stabilized to near normal values. The elevated blood glucose values recorded during circulatory insufficiency and ventilatory failure were further increased for 45 min and thereafter almost returned to base line.