Optimisation of a complexation process as a new method for obtaining a controlled morphine delivery system

2002 
A method to obtain an oral controlled morphine release system will be developed in this paper: a complexation process between Eudragit L and morphine. A preclinical study of the complex morphine-Eudragit L on rats indicated that this system had a marked analgesic effect from 30 min to 8 h. The objective of the present paper is to carry out several modifications on the initial preparation technique in order to optimise the complexation process and to establish the critical factors that affect the development of the proposed reaction. Parameters such as morphine content, morphine entrapment and weight efficiency were evaluated. An excess of drug was needed to obtain the best values of the studied reaction parameters. The lot prepared with 35% drug excess showed the biggest values of morphine entrapment and weight efficiency, being respectively 66.21 and 77.08%.
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