Soothing agents or soothing method of external stimulus response in the skin

The present invention provides a medicament for soothing response of the skin to external stimuli. An above-described problems by the discovery components that promote CD39 gene expression in Langerhans cells were resolved. Specifically it, carboxymethyl beta glucan or a salt thereof, polyoxyethylene (POE) / polyoxypropylene (POP) random copolymer dimethyl ether, and that the combination of rose water, was found to promote CD39 gene expression based on. .FIELD 1