Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study
2016
Background: The phenomenology of the clinical symptoms
indicates that disturbance of the sense of self be a core
marker of schizophrenia. Aims: To compare neural activity
related to the self/other-agency judgment in patients with
first-episode schizophrenia-spectrum disorders (FES, n = 35)
and healthy controls (HC, n = 35). Method: A functional
magnetic resonance imaging (fMRI) using motor task with
temporal distortion of the visual feedback was employed. A
task-related functional connectivity was analyzed with the use
of independent component analysis (ICA). Results: (1) During
self-agency experience, FES showed a deficit in cortical
activation in medial frontal gyrus (BA 10) and posterior
cingulate gyrus, (BA 31; P < .05, Family-Wise Error [FWE]
corrected). (2) Pooled-sample task-related ICA revealed that
the self/other-agency judgment was dependent upon
anti-correlated default mode and central-executive networks
(DMN/CEN) dynamic switching. This antagonistic mechanism was
substantially impaired in FES during the task. Discussion:
During self-agency experience, FES demonstrate deficit in
engagement of cortical midline structures along with
substantial attenuation of anti-correlated DMN/CEN activity
underlying normal self/other-agency discriminative processes.
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