Nitrogen-containing heterocyclic ring thienopyridine ketone derivative, preparation method and application thereof

The invention provides a nitrogen-containing heterocyclic ring thienopyridine ketone derivative with a structure as the first formula and salts thereof, which belong to the technical field of anti-malignant-tumor medicine, wherein R is a nitrogen-containing six-membered heterocyclic ring or a benzene nitrogen-containing six-membered heterocyclic ring. The invention also relates to the preparationmethod of the compound, and simultaneously discloses a medicine composition using the compound or pharmaceutically acceptable salts thereof as active ingredients, and the application thereof in the aspect that the compound or pharmaceutically acceptable salts as anti-malignant-tumor medicine.