Reaction of Fluorinated Ketones with Dialkyl Phosphites: An Efficient and Selective Transformation of Aryl F-Alkyl Ketones into Dialkyl Aryl-(F-alkyl)methyl Phosphates.

Abstract Aryl F -alkyl ketones smoothly reacted with a variety of dialkyl phosphites in the presence (or absence) of a tertiary amine to give the corresponding dialkyl aryl( F -alkyl)methyl phosphates in high yields. The reaction of methyl F -phenyl ketone with the sodium salt of diethyl phosphite afforded a good yield of diethyl 1-( F phenyl)ethyl phosphate. This reaction offers a new supplemental route to various polyfluorinated esters of phosphoric acid. A possible mechanism for the reaction is also described briefly.