Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism

1990 
The effects of dietary cholesterol and fatty acids on the plasma cholesterol level and rates of very low density lipopro- tein (VLDL) cholesterol secretion and low density lipoprotein (LDL) transport through LDL receptors in the liver of the ham- ster were investigated. Increases of plasma VLDL- and LDL- cholesterol levels and VLDL-cholesterol secretion from hepato- cytes were observed in animals fed a diet enriched with 0.1% cholesterol for 2 weeks in comparison with animals fed a control diet. The addition of dietary palmitic acid accelerated the effect of dietary cholesterol on plasma VLDL- and LDL-cholesterol levels and VLDL-cholesterol secretion from hepatocytes. Die- tary linoleic acid accelerated the effect of dietary cholesterol on VLDL-cholesterol secretion from hepatocytes and diminished the effect on the plasma LDL-cholesterol level. Hepatic LDL re- ceptor activity was considerably suppressed by a control diet containing 0.05% cholesterol and a further small suppression was induced by a diet enriched with 0.1% cholesterol with or without 5% palmitic acid. However, dietary linoleic acid dimi- nished the effect of dietary cholesterol on the suppression of he- patic LDL receptor activity. I These results suggest that dietary palmitic acid augments the effect of dietary cholesterol in elevating the plasma LDL-cholesterol level through accelera- tion of VLDL-cholesterol secretion from the liver, and that die- tary linoleic acid diminishes the effect of dietary cholesterol in elevating the plasma LDL-cholesterol level by preventing the suppression of hepatic LDL receptor activity induced by choles- terol.-Ohtani, H., K. Hayashi, Y. Hirata, S. Dojo, K. Naka- shima, E. Nishio, H. Kurushima, M. Saeki, and G. Kajiyama. Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism. J. Lipid Res. 1990. 31: 1413-1422.
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