INTERRELATIONS OF DRYING HEAT AND SURVIVAL OF DIFFERENT FUNGAL SPORES WITHIN THE TABLETS FORMULATION

The level of temperature plays an important role in the survival of the microorganisms, the different species of molds must grow and develop at any temperature their environment is. However, high temperature for a certain period will cause the death of microorganisms. In this study the objective is to investigate the interrelations of drying heat (55 o C for 30 minutes) used in tablets manufacture on the survival of different fungal spores (Aspergillus flavus and Penicillium spp.) at different contamination levels (10 2 , 10 4 and 10 6 ) (spores/g) within the prepared tablets. The results showed that the drying heat caused the inactivation of about 32% of Aspergillus flavus spores and 36.6 % of Penicillium spp. spores within the granules. In addition, the level of inactivation decrease with increasing the contamination level, especially with 10 6 (spores/g) which may be related to the possibility of mutation that lead