Вплив гіпоксії на оксигеновий гомеостаз та кислотно-лужний баланс організма плода та новонароджених тварин

Obtaining viable posterity is one of the urgent problems of production. The research results indicate that in the state of hypoxia are born to 30-37 % of the calves and 20-25 % of pigs and 90 % of them dies in the first hours or days after birth. However, of the known literary sources, the influence of hypoxia on oxigen homeostasis and acid-base balance of the fetus and newborn animals are not very clear. In article presents the research results of oxygen homeostasis and acid-base balance indicators of the fetus and newborn animals. It is established that depending on the degree of hypoxia action during the prenatal growth and development, calves are born in a state of mild (adequate spontaneous respiratory movements), medium (after birth had inadequate spontaneous respiratory movements) and severe hypoxia (born with no signs of respiratory or meconium in the amniotic fluid), and pigs in a state of severe hypoxia. Effect of hypoxia on the fetus causes a decrease blood pH in newborn animals that accompanied with increased content of hydrogen ions in the blood in 1,66 times. Acidotic shift in animals organism that were born in a state of hypoxia is accompanied by hypoxia and hypercapnia, decreased partial pressure of oxygen in 1,35-1,25 (p<0,01), increased partial pressure of carbon dioxide 1,56-1,37 (p<0,01). On average, the supply tissues of oxygen in calves experimental groups were in 1,25 times less than in clinically healthy calves (p<0,01). The greatest number of dead piglets and piglets in a state of hypoxia is born in the third part of the generative process. Acidotic shift in the body of the fetus and newborn animals of the experimental group is characterized by increased anaerobic glycolysis, a decrease the content of bases in the blood (p<0,01).