(±)-Gancochlearols J - N, renoprotective meroterpenoids from Ganoderma cochlear.

Abstract Five pairs of meroterpenoid enantiomers, (±)-gancochlearols J − N (1–5), were isolated from the fruiting bodies of Ganoderma cochlear. Their structures were elucidated on the basis of 1D and 2D NMR and HRESIMS data. The absolute configurations of gancochlearols J − M (1–4) were assigned by electronic circular dichroism (ECD) calculations. Biological evaluation showed that (–)-1 and (–)-2 could inhibit renal fibrosis in TGF-β1-induced rat kidney proximal tubular cells (NRK-52e).