Myelodysplastic Syndrome Occurring after Adjuvant Chemotherapy for Laryngeal Cancer.

A 67-year-old man was admitted to our hospital because of general fatigue and pancytopenia. The patient had a past history of total laryngectomy for cancer of the larynx at age 64. Following that operation Tegaful 642.0g was administered for about three years. Hematological examinations revealed a hemoglobin of 7.6 g/dl, a white cell count of 2300/μl, and a platelet count of 34000/μl. A diagnosis of myelodysplastic syndrome (RAEB-t) was made from bone marrow, which contained myeloblasts and atypical cells, and peripheral blood cells (65%). A chromosomal banding study of the bone marrow cells was normal. We speculated that the preceding adjuvant chemotherapy was probably related to the occurrence of myelodysplastic syndrome.