Observation on the change of specific antibodies in wistar rats infected with Parumogonimus skrjabini

To study the changes of serum specific antibody level in wistar rats infected with Parumogonimus skrjabini.Methods The specific antibodies against Parumogonimus skrjabini on different development stage in rats were determined by ELISA.Results The antibody against metacercaria in rat serum was found after infection 45 days and the antibody titer rose gradually.The high antibody level was examined in 60 days after infection till the test finished.The antibody against adult worm was determined after infection 80 days by ELISA,but the antibody level was low.The adult worms of Parumogonimus skrjabini were obtained in the lungs from infected wistar rats.Conclusion The antibody changes in rats infected with Parumogonimus skrjabini kept stage specificity in different development period.