Synthesis 1-Bromine -5-Phenyl-Tetrazole

The product 1-Bromine -5-phenyl-tetrazole was synthesized from benzonitrile,Br_(2) and sodium azide by cyclization and bromization. The factors influencing the synthesis were discussed and the best reaction conditions were found out. The optimum conditions were as follow: molar ratio of benzonitrile to sodium azide was 1∶1.1, the catalyst adding was 1.0 mol NH_(4)Cl, the reaction temperature was 120 ℃, and reaction time was 20h, the yield of 5Phenyl-Tetrazole reached 90%; Molar ratio of 5-Phenyl-Tetrazole to sodium hydroxide and bromine was 1∶0.96∶0.97, reaction time 4h and water as solvent, the yield of 1-bromo-5-phenyltetrazole reached 56.4%. The total yield of 1-bromine -5-phenyl-tetrazole could reach 49.1% after cyclization and bromization.