Values of magnetic resonance spectrum imaging in the diagnosis of hepatic fibrosis of rats

Objective To explore the values of magnetic resonance spectrum (MRS) in early diagnosis, quantization analysis and staging of hepatic fibrosis. Methods A rat model of hepatic fibrosis was established by the method of carbon tetracarbon (CCl4). A total of 47 SD rats were divided into model (n=40) and control (n=7) groups. 1H-MRS was performed.The model rats of hepatic fibrosis were grouped according to their pathological stages.The ratio of peak height and peak area of metabolites and lipid (Cho/Lip, Glx/Lip, Lac/Lip and Cr/Lip) were calculated and compared respectively. Results The ratios of peak height of metabolites and lipid were as follows: ratio of Cho and Lip:significant differences existed between control and grades 3 and 4 model groups (P 0.05). Conclusion The ratios of peak height and peak area of Cho/Lip, Glx/Lip and Cr/Lip are important for the staging of hepatic fibrosis. Key words: Magnetic resonance spectroscopy; Liver cirrhosis; Rats