Association of Toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risk
2016
Background: The aim of this study was to investigate the role of gene variations of Toll-like receptors (TLR) 2, 3,
and 4 on genetic susceptibility to periapical pathosis.
Material and Methods: One hundred patients were included in the study and divided into two groups as follows;
Control Group (n=50) that have root canal treatment and no periapical lesion, Patient Group (n=50) that have root
canal treatment and periapical lesion. TLR2 Arg753Gln, TLR3 (c.1377C/T) and TLR4 Asp299Gly and Thr399Ile
polymorphisms were genotyped by using PCR-RFLP. Genotypical analysis of control and patient groups were
investigated to disclose whether there is any association between periapical lesions and gene variations.
Results: There are no significant statistical differences between control and patient groups according to TLR 2
and 4 gene sequence. On the contrary, CC allele detected 74% for TLR 3 in patient group, and this difference was
found to be statistically significant (
p <
0.005).
Conclusions: According to these results, it can be suggested that patients with Toll-like receptor 3 gene polymorphisms could be susceptible to periapical pathosis.
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