Familyal Akdeniz Ateşinde( FMF) Anti-Nötrofil Sitoplazmik Antikorlar

/ Antineutrophil cytoplasmin antibodies are defined as cytoplasmin (c-ANCA) and perinuc¬lear (p-ANCA) with respect to microccopic apperance in indirect immunofluorencent assas which is the gold standard for their detection. They may be seen in other inflam¬matory diseases besides pauci-immune necrotising vasculitides which exhibit a high inci¬dence of positivity. We examined the prevalance of antineutrophil zytoplasmic antibodies in a cohort of 21 FMF patients with acute attack by using indirect flurescent antibody method. There was no positivity among the study group and controls which consisted of 20 healthy volunteers. We found 59% of antibody positivity amonf 22 active lupus patients taken as positive controls. The absolute negativity of ANCA in FMF, an inflamatory disea¬se of unknown etiology, may depend on its paathogenetic diversity from primary necrotising vasculitides and/or the different target tissues of which the disease process is direc¬ted. Anti-notrofil sitoplazmik antikorlar, belirlenmeleri icin en iyi standard olarak kabul edilen immunoiloresan teknikle, mikrospopik gorunumlerine gore, sitoplazmik (c-ANCA) ve peri-nukleer (p-ANCA) olmak uzere iki sekilde tanimlanmistir. Siklikla pozitif bulunduklari pauci-immun nekrotizan vaskulitler disinda, diger inflamatuar hastaliklarda gorunebilir¬ler. Bu calismada, akut hecmede olan 21 FMF'li hastada, indirekt floresan antikor tekni¬gini kullanarak, anti-notrofil sitoplazmik antikorlarin sikligi arastirilmistir. Aktif sikaayetleri olan 21 FMFliden olusan hasta grubu ve 20 saglikli gonulluden olusan kont¬rol grubunda hicbir pozitiflige rastlanamazken, pozitif kontrol olarak alinan 22 aktif lupuslu hastada anti-notrofil sitoplazmik antikorlarin orani %59 bulunmustur. Elde edilen veriler henuz sebebi bilinmeyen inflamatuar bir hastalik olan FMF'de mutlak ANCA negatifliginin, patogenezinin primer nekrotizan vaskulitlerden tamamen farkli bir mekanizma ile olusmasina ve/veya patogenezin yoneldigi hedefin farkliligina bagli olabilecegini du¬sunmektedir.