Celastrol induces apoptosis of gastric cancer cells by miR-21 inhibiting PI3K/Akt-NF-κB signaling pathway.

Min Sha,Jun Ye,Lixin Zhang,Zheng-yun Luan,Ya-bao Chen,Junxing Huang

Celastrol induces apoptosis of gastric cancer cells by miR-21 inhibiting PI3K/Akt-NF-κB signaling pathway.

2014

Min Sha
Jun Ye
Lixin Zhang
Zheng-yun Luan
Ya-bao Chen
Junxing Huang

Objective: Celastrol, a plant triterpene, has anticancer effects by increase of apoptosis. In the present study, the mechanism of celastrol on gastric cancer cell

Keywords:

Protein kinase B
Cancer cell
Cancer research
Internal medicine
Celastrol
Endocrinology
PI3K/AKT/mTOR pathway
Apoptosis
Signal transduction
NF-κB
Chemistry
nf κb signaling
gastric cancer cell

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