DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma

Nathan C. Sheffield,Gaëlle Pierron,Johanna Klughammer,Paul Datlinger,Andreas Schönegger,Michael Schuster,Johanna Hadler,Didier Surdez,Delphine Guillemot,Eve Lapouble,Paul Fréneaux,Jacqueline Champigneulle,Raymonde Bouvier,Diana Walder,Im Ambros,Caroline Hutter,Eva Sorz,Ana Teresa Amaral,Enrique de Álava,Katharina Schallmoser,Dirk Strunk,Beate Rinner,Bernadette Liegl-Atzwanger,Berthold Huppertz,Andreas Leithner,Gonzague de Pinieux,Philippe Terrier,V. Laurence,Jean Michon,Ruth Ladenstein,Wolfgang Holter,Reinhard Windhager,Uta Dirksen,Peter F. Ambros,Olivier Delattre,Heinrich Kovar,Christoph Bock,Eleni M. Tomazou

DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma

2017

DNA methylation sequencing and bioinformatic analyses uncover an epigenetic disease spectrum in Ewing sarcoma. These characteristic epigenome patterns correlate with state of differentiation and disease aggressiveness, and pave the way for the development of biomarkers.

Keywords:

DNA methylation
Genetics
Sarcoma
Disease
Epigenetics
Biomarker (medicine)
Epigenomics
Tumour heterogeneity
Cancer research
Epigenome
Biology
Genetic heterogeneity

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