Epidemiology and chemotherapy of newly emerging pathogens from beta hemolytic Streptococcal Group B, C and G

Resistance to antibiotics has been noted in all spe cies of streptococci however it varies from country to country. The goal of the present study was to get the knowledge about the epidemiology and chemotherapy of Streptoc occal Group B, C and G as emerging pathogens. In this stu dy 28 beta hemolytic streptococci were isolated fro m various clinical specimens from the hospitals and pathologi cal laboratories of Karachi, Pakistan from November 2013 to October 2014. Among the collected strains we identi fied 18 (64%) GBS, 8 (29%) GGS and 2 (7%) GCS. Most of the GBS and GGS strains were isolated during the rainy season of the year and the majority of the strains were collected from throat swabs. Kibry-Bauer disc diffu sion method and MIC analysis indicated that the str ains of GGS were comparatively more resistant to various antibi otics as compared to GBS. GGS strains were 50% resi stant to most macrolide antibiotics. Furthermore, these stra ins were also 39% resistant to clindamycin and 25% to penicillin, cefotaxime and ciprofloxacin. Among GBS the highest rate of resistance was observed agains t clarithromycin (43%), followed by azithromycin, ery thromycin and clindamycin (39%). GCS strains were s ensitive to all the antibiotics except being 50% clindamycin resistant. However all the strains in this study w ere sensitive to augmentin antibiotic. MIC analysis indicated that b oth GBS and GGS strains had the highest MIC against clindamycin. The findings of the present study woul d provide awareness about the epidemiology and chem otherapy of group B, C and G as the emerging pathogens among from our region.