Concomitant immunity to pulmonary metastases of a murine fibrosarcoma: influence of removal of primary tumor by radiation or surgery, of active specific immunization and treatment with Corynebacterium granulosum.

Abstract Mice having a syngeneic fibrosarcoma growing in the leg develop fewer metastases in their lungs than do normal mice when cells of the same tumor are removed from syngeneic donors and injected intravenously. This concomitant immunity can be greatly augmented by removal of the primary tumor either with local irradiation or surgery, or by treating the tumor host with Corynebacterium granulosum . Treatment of tumor bearers with heavily irradiated tumor cells did not, however, influence the magnitude of the concomitant immunity.