Efficient synthesis of highly substituted pyrroles based on the tandem reactions: intermolecular amination and Pd(II)-catalyzed intramolecular hydroamidation

A novel and efficient method for construction of polysubstituted pyrroles, which included an intermolecular amination and Pd(II)-catalyzed intramolecular hydroamidation, was developed. It was found that the reactions gave high yields (55–92%).