Application of Phyllanthus urinaria polysaccharide in preparation of anti-hepatitis B virus medicines

The invention discloses an application of a Phyllanthus urinaria polysaccharide PUIP III in the preparation of anti-hepatitis B virus medicines. The Phyllanthus urinaria polysaccharide PUIP III is composed of rhamnose, arabinose, mannose and glucose, the molar ratio of rhamnose to arabinose to mannose to glucose is 0.27:0.28:0.1:0.35, and the molecular weight of the Phyllanthus urinaria polysaccharide is 418793.5. The Phyllanthus urinaria polysaccharide is obtained through artificially extracting the medicinal plant Phyllanthus urinaria, separating and purifying. In-vitro biological activity experiments show that the PUIP III can inhibit the HBsAg and HBeAg secretion and the HBV-DNA duplication in the HepG2.2.2.15 cell culture, and has a certain in-vitro anti-HBV activity; and in-vivo activity experiments show that the PUIP III has an obvious inhibition effect on DHBVDNA in ducks, has small rebound, and can be used for preparing the anti-hepatitis B virus medicines and liver protection healthcare products.