OP-1 INTRA-INDIVIDUAL VARIATIONS IN SPERM DNA FRAGMENTATION IN MEN FROM INFERTILE COUPLES COMPARED WITH FERTILE SPERM DONORS

Background and Aim:Sperm DNA integrity (SDI) is an important factor in the prognosisof male fertility. However, it has been noted that SDI canfluctuate over time within certain individuals.The aim of this study was to analyze and compare bothwithin- and between-subject sperm DNA fragmentation (SDF)fluctuations in men presenting to an infertility clinic for semenanalysis and in fertile sperm donors.Method:Semen specimens were collected from 51 patients (PS) and from8 healthy sperm donors (DS). Between 2 and 6 SDF measurementsper patient were performed. Fertile donors provided 49 semensamples over a period of 4 months. All samples were dividedinto three groups, according to the first SDF value: SDF