Reversible Two-step Single-Crystal to Single-Crystal Phase Transitions between Desloratadine Forms I, II and III

Single-crystal to single-crystal polymorphic transformations in molecular solids are relatively rare, with changes in crystal structure more commonly leading to destruction of the parent crystal. However, the structural basis for such transitions are of considerable interest given the changes in material properties that can result. The antihistamine desloratadine displays a two-step reversible single-crystal to single-crystal phase transition during heating/cooling cycles between three conformational polymorphs: the low temperature form I, a polytypic intermediate form II and the high temperature form III. The two-step transition involves a sequential flipping of the piperidine rings of desloratadine molecules in the crystals, which induce reversible micrometre-scale contraction on heating and expansion on cooling of the largest face of a desloratadine single crystal. Distinct slow-moving phase boundaries, originating on the (001) face of the crystal, were observed sweeping through the entire crystal in h...