A reliability study of square wave bursting $\beta$-cells with noise
2011
Reliability of spike timing has been a hot topic recently. However
reliability has not been considered for bursting behavior, as
commonly observed in a variety of nerve and endocrine cells,
including $\beta$-cells in intact pancreatic islets. In this paper,
reliability of $\beta$-cells with noise is considered. A method to
numerically study reliability of bursting cells is presented.
Reliability of a single cell will decrease as noise level becomes
larger. The reliability of networks of $\beta$-cells coupled by gap
junctions or synaptic excitation is investigated. Simulations of the
network of $\beta$-cells reveal that increasing noise level
decreases the reliability. But the reliability of the network is
higher than that of single cell. The effect of coupling strength on
reliability is also investigated. Reliability will decrease when
coupling strength is small and increase when coupling strength is
large.
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