Effect of Active Oxygen on Guanidine Synthesis in Vitro

Recently there have been many reports describing the toxicity of oxygen in various disease states 1–4. Some investigators have reported that patients with chronic renal failure are in a stronger peroxidative state than normal persons5–9. We have reported that methylguanidine (MG) is a peroxidative product of creatinine (CRN) and that the hydroxyl radical plays an important role in MG synthesis both in vitro and in isolated rat hepatoeytes. We also suggest that MG is a useful indicator of peroxidation in uremic serum10–13.