IS DIABETES MELLITUS A RISK FACTOR FOR CONGENITAL ANOMALIES OF THE KIDNEY AND URINARY TRACT (CAKUT)

Background: Congenital anomalies of kidney and urinary tract (CAKUT) are characterized by structural and functional abnormalities of kidney, collecting system, bladder, and urethra [1]. In Egypt, CAKUT comprised 46% of the underlying etiology in Egyptian CKD pediatric patients [2]. Evolving studies postulating CAKUT and related risk factors addressed diabetes mellitus (DM) as one of preventable risk factors. However more is needed to address the pattern of DM exposure during pregnancy in relation to CAKUT occurrence. Study Design: Retrospective case-control study from April 2018 –November 2020. Setting & Participants: Children aged (0-5) diagnosed with CAKUT attending Minia University Hospitals and their controls Methodology: Questionnaire data were collected from mothers of 150 children with CAKUT and 150 healthy controls. Maternal risk factors investigated included maternal age, residence, history of obesity during pregnancy and diabetes mellitus. Logistic regression analyses were performed to assess associations between these potential risk factors and CAKUT occurrence.