The nicotinamide coenzyme system in experimental burn disease during prepubescence

: Distinct impairments were observed in metabolism of nicotinamide coenzymes in liver tissue of preadolescent rats with severe thermic burns: a decrease in total content of the coenzymes, a decrease in content of oxidized forms and elevation of reduced derivatives, inhibition of biosynthesis and stimulation of the nicotinamide coenzymes catabolism, especially high during acute period of burns. Nicotinamide, administered at a dose of 50 mg/kg into animals, was shown to correct the coenzymes content and activity of glyceraldehydephosphate dehydrogenase in liver tissue of rats with burns.