Effects of selective digestive tract decontamination on intestinal permeability in cirrhosis spontaneous bacterial peritonitis

Objective To study the intestinal permeability changes and the effects of the selective digestive tract decontamination(SDD) in the cirrhosis patients with spontaneous bacterial peritonitis(SBP).Methods According to the cirrhosis SBP diagnostic criteria,28 diagnosed patients were randomly divided into two groups: treatment group(15 cases) and control group(13 cases).All the patients were administered the cirrhotic ascitis conventional therapy and antibiotics,besides that,the patients in the treatment group were orally given Norfloxacin as SDD.The serum diamine oxidase(DAO),D-lactate(D-Lac) and endotoxin(ET) were measured by enzyme linked immune absorbent(ELISA) before and after the treatment,the intestinal mucosal barrier microstructure was microscopically examined with hematoxylin eosin stain.Results The conventional therapy could decrease the serum levels of DAO,D-Lac and ET(P0.05),SDD could furthermore alleviate the intestinal mucosal injury,lower the intestinal mucosal permeability and prevent the bacterial and ET translocation(P0.05).Conclusion The SDD has the prophylactic effect on the intestinal barrier of the cirrhosis SBP.