Recipient Related Predictors of Kidney Transplantation Outcomes in the Elderly - eScholarship

2013 
BackgroundIt is not clear whether in old people with end-stage renal disease kidney transplantation is superior to dialysis therapy.MethodsWe compared mortality rates between kidney transplant recipients (KTRs) and the general population across different age categories. We also examined patient and allograft survival in 15,667 elderly KTRs (65– 30 kg/m2) was associated with 19% higher risk of graft failure (HR:1.19 [1.07–1.33], p = 0.002). Diabetes was a predictor of worse patient survival in all age groups but poorer allograft outcome in the youngest age group (65–<70 years-old) only. None of the examined risk factors affected allograft outcome in the oldest group (≥75 years-old) although there was a 49% lower trend of graft failure in very old Hispanic recipients (HR:0.51 [0.26–1.01], p = 0.05).ConclusionsKidney transplantation may attenuate the age-associated increase in mortality, and its superior survival gain is most prominent in the oldest recipients (≥75 years-old). The potential protective effect of kidney transplantation on longevity in the elderly deserves further investigation.
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