Structure and dynamics of proteins by high-resolution solid-state NMR

Solid - state NMR spectroscopy has signific antly grown in recent years, and is rapidly becoming a powerful structural tool in chemistry and biology. Steadily ongoing methodological developments combined with tremendous engineering advances in probe and spectrometer hardware, along with notably incr eased magnetic field strengths, have paved the way for studying the structure and dynamics of solid chemical and biological samples at atomic resolution spanning a broad atlas of structures ranging from materials to protein aggregates or membrane proteins . T his lecture presents an outline of this experimental technique, of its recent progress, and of its immense potential. As a case study, the structural and dynamical determination of a paramagnetic human enzyme, the Cu II ,Zn II - superoxide dismutase, in micro crystalline form will be presented