Identification of target engagement biomarkers for MARK inhibitor discovery using quantitative mass spectrometry

decrease in intracellular vitamin E was associated with the deterioration in cognitive performance. The correlation between oxidative changes and mitochondral dysfunction will be established. Conclusions: These results suggest that accumulation of oxidative damage may start in pre-symptomatic phases of AD pathology and that progression to AD might be related to deplection of antioxidant defenses. This work was supported by the Portuguese Foundation for Science and Technology (FCT) through PIC/ IC/83206/2007