Роль макрофагов в регуляции биосинтеза белка в клетках асцитной карциномы Эрлиха

The role of peritoneal macrophages of mice with Ehrlich carcinoma in uptake and metabolic degradation of a protein component of high density lipoproteins has been studied. Stimulating effect of cortisol on these processes has been revealed. Differences in spectra of endocellular proteins between tumor-associated macrophages and peritoneal macrophages of healthy mice, in particular, in the level of apolipoprotein E have been shown. Participation of macrophages in the regulation of the protein biosynthesis rate in tumor cells under the influence of high density lipoproteins and cortisol has been shown. Apolipoprotein Е can play a role of a negative feedback in the mechanism of increasing the rate of protein biosynthesis in tumor cells.