The QT Interval in Patients With the Turner Syndrome.

ABSTRACT Patients with the Turner syndrome (TS) often have longer QT intervals compared to age matched peers although the significance of this remains unknown. We sought to determine the degree, frequency and impact of QTc prolongation in patients with TS. A chart review of all patients with an electrocardiogram (ECG) and genetically-proven TS was performed. Medications at the time of the ECG were reviewed and QTc calculated. Medications were classified according to QTc risk using www.crediblemeds.com . ECG parameters were compared to an age, gender, and cardiac lesion-matched control group. Over the 10-year period of review, 112 TS patients with a mean age of 34±25 years underwent 226 ECGs. At least 1QTc prolonging medication was prescribed in 81 (74%) patients. Longer QTc interval correlated with absence of y chromosomal material (p=0.01), older age (p 460 msec (2.8% vs 2.6%, p=0.9). In conclusion, despite frequent use of QT-prolonging medications, ventricular arrhythmias are rare in TS.