Role of prostaglandins in the regulation of catecholamine uptake by the myocardium

The study of the effect of prostaglandin E1 (PG-E1) on catecholamine uptake by homogenates of albino rat myocardium showed that in concentrations of 2×10−6M PG-E1 considerably inhibits the uptake of adrenalin and causes some decrease in the uptake of noradrenalin by the heart muscle. Neither PG-E1 nor PG-A1 (in concentrations of between 2×10−10 and 2×10−6M) had any effect on interaction between troponin and noradrenalin: The intensity of luminescence of troponin in the presence of noradrenalin was unchanged on the addition of PG-E1 and PG-A1. The ability of PG to reduce catecholamine uptake by the myocardium is not due to its effect on the interaction between troponin and catecholamines, but depends on different mechanisms.